# Pembrolizumab and Vorinostat in Treating Patients With Recurrent Squamous Cell Head and Neck Cancer or Salivary Gland Cancer That Is Metastatic and/or Cannot Be Removed by Surgery

> **NCT02538510** · PHASE1,PHASE2 · COMPLETED · sponsor: **University of Washington** · enrollment: 50 (actual)

## Conditions studied

- Head and Neck Squamous Cell Carcinoma
- Recurrent Nasal Cavity and Paranasal Sinus Squamous Cell Carcinoma
- Recurrent Nasopharynx Carcinoma
- Recurrent Salivary Gland Carcinoma
- Squamous Cell Carcinoma Metastatic in the Neck With Occult Primary
- Stage III Major Salivary Gland Carcinoma
- Stage III Nasal Cavity and Paranasal Sinus Squamous Cell Carcinoma
- Stage III Nasopharyngeal Carcinoma
- Stage IV Nasopharyngeal Carcinoma
- Stage IVA Major Salivary Gland Carcinoma
- Stage IVA Nasal Cavity and Paranasal Sinus Squamous Cell Carcinoma
- Stage IVB Major Salivary Gland Carcinoma
- Stage IVB Nasal Cavity and Paranasal Sinus Squamous Cell Carcinoma
- Stage IVC Major Salivary Gland Carcinoma
- Stage IVC Nasal Cavity and Paranasal Sinus Squamous Cell Carcinoma

## Interventions

- **OTHER:** Laboratory Biomarker Analysis
- **BIOLOGICAL:** Pembrolizumab
- **DRUG:** Vorinostat

## Key facts

- **NCT ID:** NCT02538510
- **Lead sponsor:** University of Washington
- **Sponsor class:** OTHER
- **Phase:** PHASE1,PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2015-10-08
- **Primary completion:** 2019-09-28
- **Final completion:** 2023-09-15
- **Target enrollment:** 50 (ACTUAL)
- **Last updated:** 2024-11-26

## Collaborators

- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT02538510

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT02538510, "Pembrolizumab and Vorinostat in Treating Patients With Recurrent Squamous Cell Head and Neck Cancer or Salivary Gland Cancer That Is Metastatic and/or Cannot Be Removed by Surgery". Retrieved via AI Analytics 2026-05-28 from https://api.ai-analytics.org/clinical/NCT02538510. Licensed CC0.

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