# Enzalutamide With Ribociclib in Treating Patients With Metastatic Castrate-Resistant, Chemotherapy Naive Prostate Cancer That Retains Retinoblastoma Expression

> **NCT02555189** · PHASE1,PHASE2 · TERMINATED · sponsor: **Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University** · enrollment: 52 (actual)

## Conditions studied

- Castration-Resistant Prostate Carcinoma
- Metastatic Prostate Carcinoma
- Prostate Carcinoma Metastatic in the Bone
- Stage IV Prostate Cancer AJCC v7

## Interventions

- **DRUG:** Enzalutamide
- **DRUG:** Ribociclib
- **OTHER:** Laboratory Biomarker Analysis
- **OTHER:** Pharmacological Study
- **PROCEDURE:** Biospecimen Collection
- **PROCEDURE:** Biopsy
- **PROCEDURE:** Echocardiography
- **PROCEDURE:** Multigated Acquisition Scan
- **PROCEDURE:** Bone Scan
- **PROCEDURE:** Computed Tomography
- **PROCEDURE:** Magnetic Resonance Imaging

## Key facts

- **NCT ID:** NCT02555189
- **Lead sponsor:** Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University
- **Sponsor class:** OTHER
- **Phase:** PHASE1,PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** TERMINATED
- **Start date:** 2015-12-01
- **Primary completion:** 2022-12-07
- **Final completion:** 2023-09-01
- **Target enrollment:** 52 (ACTUAL)
- **Why stopped:** Sponsor-PI decision. An analysis of the primary endpoint concluded that the addition of ribociclib to standard of care enzalutamide did not demonstrate benefit, an all active subjects were removed from the study.
- **Last updated:** 2026-04-22

## Collaborators

- [object Object]
- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT02555189

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT02555189, "Enzalutamide With Ribociclib in Treating Patients With Metastatic Castrate-Resistant, Chemotherapy Naive Prostate Cancer That Retains Retinoblastoma Expression". Retrieved via AI Analytics 2026-05-28 from https://api.ai-analytics.org/clinical/NCT02555189. Licensed CC0.

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