Reduced Intensity Chemotherapy and Radiation Therapy Before Donor Stem Cell Transplant in Treating Patients With Hematologic Malignancies

NCT02566304 · clinicaltrials.gov ↗

PHASE2

Phase

COMPLETED

Status

35

Enrollment

OTHER

Sponsor class

Conditions

Acute Myeloid Leukemia
Acute Myeloid Leukemia in Remission
Aplastic Anemia
Chronic Myelomonocytic Leukemia
Hodgkin Lymphoma
Indolent Non-Hodgkin Lymphoma
Malignant Neoplasm
Myelodysplastic Syndrome
Myeloproliferative Neoplasm
Plasma Cell Myeloma
Refractory Anemia
Refractory Anemia With Excess Blasts
Refractory Anemia With Ring Sideroblasts
Refractory Cytopenia With Multilineage Dysplasia
Refractory Cytopenia With Multilineage Dysplasia and Ring Sideroblasts

Interventions

DRUG: Fludarabine
RADIATION: Total-Body Irradiation
BIOLOGICAL: T Cell-Depleted Donor Lymphocyte Infusion
DRUG: Cyclophosphamide
PROCEDURE: Peripheral Blood Stem Cell Transplantation
PROCEDURE: Allogeneic Hematopoietic Stem Cell Transplantation
DRUG: Tacrolimus
DRUG: Mycophenolate mofetil
OTHER: Laboratory Biomarker Analysis

Sponsor

Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University