# Reduced Intensity Chemotherapy and Radiation Therapy Before Donor Stem Cell Transplant in Treating Patients With Hematologic Malignancies

> **NCT02566304** · PHASE2 · COMPLETED · sponsor: **Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University** · enrollment: 35 (actual)

## Conditions studied

- Acute Myeloid Leukemia
- Acute Myeloid Leukemia in Remission
- Aplastic Anemia
- Chronic Myelomonocytic Leukemia
- Hodgkin Lymphoma
- Indolent Non-Hodgkin Lymphoma
- Malignant Neoplasm
- Myelodysplastic Syndrome
- Myeloproliferative Neoplasm
- Plasma Cell Myeloma
- Refractory Anemia
- Refractory Anemia With Excess Blasts
- Refractory Anemia With Ring Sideroblasts
- Refractory Cytopenia With Multilineage Dysplasia
- Refractory Cytopenia With Multilineage Dysplasia and Ring Sideroblasts

## Interventions

- **DRUG:** Fludarabine
- **RADIATION:** Total-Body Irradiation
- **BIOLOGICAL:** T Cell-Depleted Donor Lymphocyte Infusion
- **DRUG:** Cyclophosphamide
- **PROCEDURE:** Peripheral Blood Stem Cell Transplantation
- **PROCEDURE:** Allogeneic Hematopoietic Stem Cell Transplantation
- **DRUG:** Tacrolimus
- **DRUG:** Mycophenolate mofetil
- **OTHER:** Laboratory Biomarker Analysis

## Key facts

- **NCT ID:** NCT02566304
- **Lead sponsor:** Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University
- **Sponsor class:** OTHER
- **Phase:** PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2015-11-13
- **Primary completion:** 2024-02-13
- **Final completion:** 2024-02-13
- **Target enrollment:** 35 (ACTUAL)
- **Last updated:** 2025-04-24


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT02566304

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT02566304, "Reduced Intensity Chemotherapy and Radiation Therapy Before Donor Stem Cell Transplant in Treating Patients With Hematologic Malignancies". Retrieved via AI Analytics 2026-06-02 from https://api.ai-analytics.org/clinical/NCT02566304. Licensed CC0.

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