# Efficacy and Safety of Autologous Cultivated Limbal Stem Cells Transplantation (ACLSCT) for Restoration of Corneal Epithelium in Patients With Limbal Stem Cell Deficiency

> **NCT02577861** · PHASE4 · COMPLETED · sponsor: **Holostem s.r.l.** · enrollment: 70 (estimated)

## Conditions studied

- Limbal Stem Cells Deficiency

## Interventions

- **PROCEDURE:** Biopsy from donor eye
- **PROCEDURE:** Implant of Holoclar
- **PROCEDURE:** Ophtalmologic examination
- **PROCEDURE:** Blood sample collection
- **PROCEDURE:** Digital pictures
- **PROCEDURE:** ECG
- **BEHAVIORAL:** Questionnaires
- **PROCEDURE:** Physical examination and vital signs

## Key facts

- **NCT ID:** NCT02577861
- **Lead sponsor:** Holostem s.r.l.
- **Sponsor class:** INDUSTRY
- **Phase:** PHASE4
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2015-10
- **Primary completion:** 2020-12
- **Final completion:** 2022-03-11
- **Target enrollment:** 70 (ESTIMATED)
- **Last updated:** 2022-04-01


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT02577861

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT02577861, "Efficacy and Safety of Autologous Cultivated Limbal Stem Cells Transplantation (ACLSCT) for Restoration of Corneal Epithelium in Patients With Limbal Stem Cell Deficiency". Retrieved via AI Analytics 2026-06-02 from https://api.ai-analytics.org/clinical/NCT02577861. Licensed CC0.

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