Testing the Addition of an Experimental Medication MK-3475 (Pembrolizumab) to Usual Anti-Retroviral Medications in Patients With HIV and Cancer

Conditions

• AIDS-Related Non-Hodgkin Lymphoma
• Clinical Stage III Cutaneous Melanoma AJCC v8
• Clinical Stage IV Cutaneous Melanoma AJCC v8
• Hepatocellular Carcinoma
• HIV Infection
• Kaposi Sarcoma
• Locally Advanced Lung Non-Small Cell Carcinoma
• Locally Advanced Malignant Solid Neoplasm
• Metastatic Lung Non-Small Cell Carcinoma
• Metastatic Malignant Solid Neoplasm
• Metastatic Melanoma
• Non-Hodgkin Lymphoma
• Recurrent Classic Hodgkin Lymphoma
• Recurrent Malignant Neoplasm
• Refractory Classic Hodgkin Lymphoma
• Refractory Malignant Neoplasm
• Stage III Lung Cancer AJCC v8
• Stage IV Lung Cancer AJCC v8
• Unresectable Melanoma

Interventions

• DRUG: Antiretroviral Therapy
• PROCEDURE: Biopsy
• PROCEDURE: Biospecimen Collection
• PROCEDURE: Computed Tomography
• BIOLOGICAL: Pembrolizumab
• PROCEDURE: Positron Emission Tomography

Sponsor

National Cancer Institute (NCI)