# Triapine With Chemotherapy and Radiation Therapy in Treating Patients With IB2-IVA Cervical or Vaginal Cancer

> **NCT02595879** · PHASE1 · ACTIVE_NOT_RECRUITING · sponsor: **National Cancer Institute (NCI)** · enrollment: 21 (actual)

## Conditions studied

- Advanced Cervical Adenocarcinoma
- Advanced Cervical Adenosquamous Carcinoma
- Advanced Cervical Squamous Cell Carcinoma
- Advanced Vaginal Adenocarcinoma
- Advanced Vaginal Adenosquamous Carcinoma
- Advanced Vaginal Squamous Cell Carcinoma
- Stage IB2 Cervical Cancer AJCC v6 and v7
- Stage II Cervical Cancer AJCC v7
- Stage II Vaginal Cancer AJCC v6 and v7
- Stage III Vaginal Cancer AJCC v6 and v7
- Stage IIIB Cervical Cancer AJCC v6 and v7
- Stage IVA Cervical Cancer AJCC v6 and v7
- Stage IVA Vaginal Cancer AJCC v6 and v7

## Interventions

- **PROCEDURE:** Biospecimen Collection
- **RADIATION:** Brachytherapy
- **DRUG:** Cisplatin
- **PROCEDURE:** Computed Tomography
- **RADIATION:** External Beam Radiation Therapy
- **OTHER:** Fludeoxyglucose F-18
- **RADIATION:** High-Dose Rate Brachytherapy
- **RADIATION:** Intensity-Modulated Radiation Therapy
- **PROCEDURE:** Magnetic Resonance Imaging
- **OTHER:** Pharmacological Study
- **PROCEDURE:** Positron Emission Tomography
- **DRUG:** Triapine

## Key facts

- **NCT ID:** NCT02595879
- **Lead sponsor:** National Cancer Institute (NCI)
- **Sponsor class:** NIH
- **Phase:** PHASE1
- **Study type:** INTERVENTIONAL
- **Status:** ACTIVE_NOT_RECRUITING
- **Start date:** 2019-09-18
- **Primary completion:** 2023-06-04
- **Final completion:** 2026-04-29
- **Target enrollment:** 21 (ACTUAL)
- **Last updated:** 2026-04-29


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT02595879

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT02595879, "Triapine With Chemotherapy and Radiation Therapy in Treating Patients With IB2-IVA Cervical or Vaginal Cancer". Retrieved via AI Analytics 2026-06-05 from https://api.ai-analytics.org/clinical/NCT02595879. Licensed CC0.

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