# L-carnitine as an Adjunct Treatment for Septic Shock Patients With Acute Kidney Injury

> **NCT02664753** · PHASE3 · TERMINATED · sponsor: **Centre Hospitalier Universitaire de Nīmes** · enrollment: 254 (actual)

## Conditions studied

- Severe Sepsis
- Shock, Septic
- Acute Kidney Injury

## Interventions

- **DRUG:** 56 days of weight-adjusted L-Carnitine treatment
- **DRUG:** 10 days of intravenous placebo (isotonic saline)

## Key facts

- **NCT ID:** NCT02664753
- **Lead sponsor:** Centre Hospitalier Universitaire de Nīmes
- **Sponsor class:** OTHER
- **Phase:** PHASE3
- **Study type:** INTERVENTIONAL
- **Status:** TERMINATED
- **Start date:** 2018-03-05
- **Primary completion:** 2024-12-04
- **Final completion:** 2024-12-04
- **Target enrollment:** 254 (ACTUAL)
- **Why stopped:** Exposure to serious adverse events related to the research (i.e., death), the mnts = 54% versus 58 deaths out of 121 patients = 48%).onitoring committee unanimously recommended discontinuation of the trial.
- **Last updated:** 2025-08-26


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT02664753

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT02664753, "L-carnitine as an Adjunct Treatment for Septic Shock Patients With Acute Kidney Injury". Retrieved via AI Analytics 2026-06-02 from https://api.ai-analytics.org/clinical/NCT02664753. Licensed CC0.

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