Study of Efficacy and Safety of Dabrafenib in Combination With Trametinib in Pediatric Patients With BRAF V600 Mutation Positive LGG or Relapsed or Refractory HGG Tumors

Conditions

• Diffuse Astrocytoma
• Anaplastic Astrocytoma
• Astrocytoma
• Oligodendroglioma, Childhood
• Anaplastic Oligodendroglioma
• Glioblastoma
• Pilocytic Astrocytoma
• Giant Cell Astrocytoma
• Pleomorphic Xanthoastrocytoma
• Anaplastic Pleomorphic Xanthoastrocytoma
• Angiocentric Glioma
• Chordoid Glioma of Third Ventricle
• Gangliocytoma
• Ganglioglioma
• Anaplastic Ganglioglioma
• Dysplastic Gangliocytoma of Cerebrellum
• Desmoplastic Infantile Astrocytoma and Ganglioglioma
• Papillary Glioneuronal Tumor
• Rosette-forming Glioneurona Tumor
• Central Neurocytoma
• Extraventricular Neurocytoma
• Cerebellar Iponeurocytoma

Interventions

• DRUG: Dabrafenib
• DRUG: trametinib
• DRUG: Carboplatin
• DRUG: Vincristine

Sponsor

Novartis Pharmaceuticals