# Phase II Study of Intraventricular Methotrexate in Children With Recurrent or Progressive Malignant Brain Tumors

> **NCT02684071** · PHASE2 · TERMINATED · sponsor: **Nicklaus Children's Hospital f/k/a Miami Children's Hospital** · enrollment: 3 (actual)

## Conditions studied

- Recurrent Childhood Medulloblastoma
- Recurrent Childhood Ependymoma
- Childhood Atypical Teratoid/Rhabdoid Tumor
- Embryonal Tumor With Abundant Neuropil and True Rosettes
- Metastatic Malignant Neoplasm to the Leptomeninges

## Interventions

- **DRUG:** Intra thecal methotrexate
- **DRUG:** topotecan
- **DRUG:** cyclophosphamide

## Key facts

- **NCT ID:** NCT02684071
- **Lead sponsor:** Nicklaus Children's Hospital f/k/a Miami Children's Hospital
- **Sponsor class:** OTHER
- **Phase:** PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** TERMINATED
- **Start date:** 2016-02
- **Primary completion:** 2019-12-09
- **Final completion:** 2019-12-09
- **Target enrollment:** 3 (ACTUAL)
- **Why stopped:** Lack of additional funding; patients (3) no longer receiving intervention.
- **Last updated:** 2020-01-10


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT02684071

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT02684071, "Phase II Study of Intraventricular Methotrexate in Children With Recurrent or Progressive Malignant Brain Tumors". Retrieved via AI Analytics 2026-05-29 from https://api.ai-analytics.org/clinical/NCT02684071. Licensed CC0.

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