# A Pilot Study Investigating the Efficacy of Minocycline and N-Acetyl Cysteine for Bipolar Depression

> **NCT02719392** · PHASE4 · SUSPENDED · sponsor: **Massachusetts General Hospital** · enrollment: 40 (estimated)

## Conditions studied

- Bipolar Disorder
- Bipolar Depression

## Interventions

- **DIETARY_SUPPLEMENT:** N-acetylcysteine
- **DRUG:** Minocycline
- **OTHER:** Placebo

## Key facts

- **NCT ID:** NCT02719392
- **Lead sponsor:** Massachusetts General Hospital
- **Sponsor class:** OTHER
- **Phase:** PHASE4
- **Study type:** INTERVENTIONAL
- **Status:** SUSPENDED
- **Start date:** 2017-08-09
- **Primary completion:** 2026-06
- **Final completion:** 2026-08
- **Target enrollment:** 40 (ESTIMATED)
- **Why stopped:** Due to limited study staff and the COVID-19 pandemic, enrollment has been paused as staff hours for this project have been reduced and reallocated to other projects.
- **Last updated:** 2025-05-18


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT02719392

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT02719392, "A Pilot Study Investigating the Efficacy of Minocycline and N-Acetyl Cysteine for Bipolar Depression". Retrieved via AI Analytics 2026-06-02 from https://api.ai-analytics.org/clinical/NCT02719392. Licensed CC0.

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