# Reduced Craniospinal Radiation Therapy and Chemotherapy in Treating Younger Patients With Newly Diagnosed WNT-Driven Medulloblastoma

> **NCT02724579** · PHASE2 · ACTIVE_NOT_RECRUITING · sponsor: **Children's Oncology Group** · enrollment: 45 (estimated)

## Conditions studied

- Medulloblastoma

## Interventions

- **DRUG:** Cisplatin
- **DRUG:** Cyclophosphamide
- **OTHER:** Laboratory Biomarker Analysis
- **DRUG:** Lomustine
- **PROCEDURE:** Magnetic Resonance Imaging
- **RADIATION:** Radiation Therapy
- **DRUG:** Vincristine
- **DRUG:** Vincristine Sulfate

## Key facts

- **NCT ID:** NCT02724579
- **Lead sponsor:** Children's Oncology Group
- **Sponsor class:** NETWORK
- **Phase:** PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** ACTIVE_NOT_RECRUITING
- **Start date:** 2017-11-17
- **Primary completion:** 2028-03-31
- **Final completion:** 2028-03-31
- **Target enrollment:** 45 (ESTIMATED)
- **Last updated:** 2026-05-05

## Collaborators

- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT02724579

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT02724579, "Reduced Craniospinal Radiation Therapy and Chemotherapy in Treating Younger Patients With Newly Diagnosed WNT-Driven Medulloblastoma". Retrieved via AI Analytics 2026-06-04 from https://api.ai-analytics.org/clinical/NCT02724579. Licensed CC0.

---

*[Clinical trials dataset](/datasets/clinical-trials) · CC0 1.0*