# HLA-Mismatched Unrelated Donor Bone Marrow Transplantation With Post-Transplantation Cyclophosphamide

> **NCT02793544** · PHASE2 · COMPLETED · sponsor: **Center for International Blood and Marrow Transplant Research** · enrollment: 80 (actual)

## Conditions studied

- Myelodysplastic Syndrome (MDS)
- Chronic Lymphocytic Leukemia (CLL)
- Chemotherapy-sensitive Lymphoma
- Acute Lymphoblastic Leukemia (ALL)/T Lymphoblastic Lymphoma
- Acute Myelogenous Leukemia (AML)
- Acute Biphenotypic Leukemia (ABL)
- Acute Undifferentiated Leukemia (AUL)

## Interventions

- **DRUG:** Fludarabine
- **DRUG:** Cyclophosphamide 14.5 mg/kg/day IV on Days -6, -5
- **RADIATION:** Total Body Irradiation (TBI) 200cGy on Day -1
- **PROCEDURE:** Infusion of non-T-cell depleted bone marrow on Day 0
- **DRUG:** Busulfan
- **DRUG:** Cyclophosphamide 50mg/kg/day IV on Days -2,-1
- **DRUG:** Cyclophosphamide 50mg/kg/day IV on Days -5,-4
- **RADIATION:** Total Body Irradiation (TBI) 200cGy twice a day on Days -3, -2, -1
- **DRUG:** Post-HCT Cyclophosphamide 50mg/kg IV on Day+3, +4
- **DRUG:** Sirolimus
- **DRUG:** Mycophenolate mofetil
- **DRUG:** G-CSF
- **DRUG:** Pre-HCT Mesna on Days -6 and -5
- **DRUG:** Pre-HCT Mesna on Days -2 and -1
- **DRUG:** Pre-HCT Mesna on Days -5 and -4
- **DRUG:** Post-HCT Mesna

## Key facts

- **NCT ID:** NCT02793544
- **Lead sponsor:** Center for International Blood and Marrow Transplant Research
- **Sponsor class:** NETWORK
- **Phase:** PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2016-12
- **Primary completion:** 2020-03
- **Final completion:** 2020-03
- **Target enrollment:** 80 (ACTUAL)
- **Last updated:** 2025-08-06

## Collaborators

- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT02793544

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT02793544, "HLA-Mismatched Unrelated Donor Bone Marrow Transplantation With Post-Transplantation Cyclophosphamide". Retrieved via AI Analytics 2026-06-24 from https://api.ai-analytics.org/clinical/NCT02793544. Licensed CC0.

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