# Durvalumab and Tremelimumab in Treating Patients With Muscle-Invasive, High-Risk Urothelial Cancer That Cannot Be Treated With Cisplatin-Based Therapy Before Surgery

> **NCT02812420** · EARLY_PHASE1 · ACTIVE_NOT_RECRUITING · sponsor: **M.D. Anderson Cancer Center** · enrollment: 54 (actual)

## Conditions studied

- Hydronephrosis
- Infiltrating Bladder Urothelial Carcinoma Sarcomatoid Variant
- Infiltrating Bladder Urothelial Carcinoma, Micropapillary Variant
- Infiltrating Bladder Urothelial Carcinoma, Plasmacytoid Variant
- Infiltrating Renal Pelvis Urothelial Carcinoma, Sarcomatoid Variant
- Renal Pelvis Urothelial Carcinoma
- Stage II Bladder Urothelial Carcinoma AJCC v6 and v7
- Stage II Renal Pelvis Cancer AJCC v7
- Stage II Ureter Cancer AJCC v7
- Stage II Urethral Cancer AJCC v7
- Stage III Bladder Urothelial Carcinoma AJCC v6 and v7
- Stage III Renal Pelvis Cancer AJCC v7
- Stage III Ureter Cancer AJCC v7
- Stage III Urethral Cancer AJCC v7
- Stage IV Renal Pelvis Cancer AJCC v7
- Stage IV Ureter Cancer AJCC v7
- Stage IV Urethral Cancer AJCC v7
- Ureter Urothelial Carcinoma
- Urethral Urothelial Carcinoma

## Interventions

- **BIOLOGICAL:** Durvalumab
- **PROCEDURE:** Therapeutic Conventional Surgery
- **BIOLOGICAL:** Tremelimumab

## Key facts

- **NCT ID:** NCT02812420
- **Lead sponsor:** M.D. Anderson Cancer Center
- **Sponsor class:** OTHER
- **Phase:** EARLY_PHASE1
- **Study type:** INTERVENTIONAL
- **Status:** ACTIVE_NOT_RECRUITING
- **Start date:** 2017-03-07
- **Primary completion:** 2027-12-31
- **Final completion:** 2027-12-31
- **Target enrollment:** 54 (ACTUAL)
- **Last updated:** 2026-03-05

## Collaborators

- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT02812420

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT02812420, "Durvalumab and Tremelimumab in Treating Patients With Muscle-Invasive, High-Risk Urothelial Cancer That Cannot Be Treated With Cisplatin-Based Therapy Before Surgery". Retrieved via AI Analytics 2026-06-01 from https://api.ai-analytics.org/clinical/NCT02812420. Licensed CC0.

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