Azacitidine and Combination Chemotherapy in Treating Infants With Acute Lymphoblastic Leukemia and KMT2A Gene Rearrangement

NCT02828358 · clinicaltrials.gov ↗

PHASE2

Phase

COMPLETED

Status

78

Enrollment

NIH

Sponsor class

Conditions

Acute Leukemia of Ambiguous Lineage
B Acute Lymphoblastic Leukemia
Mixed Phenotype Acute Leukemia

Interventions

DRUG: Azacitidine
PROCEDURE: Biospecimen Collection
PROCEDURE: Computed Tomography
DRUG: Cyclophosphamide
DRUG: Cytarabine
DRUG: Daunorubicin
DRUG: Daunorubicin Hydrochloride
DRUG: Dexamethasone
PROCEDURE: Echocardiography
DRUG: Hydrocortisone Sodium Succinate
DRUG: Leucovorin
DRUG: Leucovorin Calcium
PROCEDURE: Magnetic Resonance Imaging
DRUG: Mercaptopurine
DRUG: Methotrexate
PROCEDURE: Multigated Acquisition Scan
DRUG: Pegaspargase
DRUG: Prednisolone
DRUG: Thioguanine
DRUG: Vincristine

Sponsor

National Cancer Institute (NCI)