# Defibrotide in the Human Endotoxemia Model --- an Exploratory Trial Investigating the Effects and the Mechanisms of Defibrotide

> **NCT02876601** · PHASE4 · COMPLETED · sponsor: **Bernd Jilma** · enrollment: 20 (actual)

## Conditions studied

- Healthy Volunteers
- Endotoxemia

## Interventions

- **DRUG:** Defibrotide
- **DRUG:** Placebo (0.9% sodium chloride)
- **DRUG:** Lipopolysaccharide
- **DRUG:** Placebo (0.9% sodium chloride bolus)

## Key facts

- **NCT ID:** NCT02876601
- **Lead sponsor:** Bernd Jilma
- **Sponsor class:** OTHER
- **Phase:** PHASE4
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2017-04-18
- **Primary completion:** 2018-02-12
- **Final completion:** 2018-02-12
- **Target enrollment:** 20 (ACTUAL)
- **Last updated:** 2019-12-19


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT02876601

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT02876601, "Defibrotide in the Human Endotoxemia Model --- an Exploratory Trial Investigating the Effects and the Mechanisms of Defibrotide". Retrieved via AI Analytics 2026-06-16 from https://api.ai-analytics.org/clinical/NCT02876601. Licensed CC0.

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