# Optimizing Outcomes of Treatment-Resistant Depression in Older Adults

> **NCT02960763** · PHASE4 · COMPLETED · sponsor: **Washington University School of Medicine** · enrollment: 742 (actual)

## Conditions studied

- Treatment Resistant Depression
- Major Depressive Disorder
- Treatment-Refractory Depression
- Late Life Depression
- Geriatric Depression

## Interventions

- **DRUG:** Aripiprazole Augmentation
- **DRUG:** Bupropion Augmentation
- **DRUG:** Switch to bupropion
- **DRUG:** Lithium Augmentation
- **DRUG:** Switch to nortriptyline

## Key facts

- **NCT ID:** NCT02960763
- **Lead sponsor:** Washington University School of Medicine
- **Sponsor class:** OTHER
- **Phase:** PHASE4
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2017-02-24
- **Primary completion:** 2020-09-28
- **Final completion:** 2021-09-01
- **Target enrollment:** 742 (ACTUAL)
- **Last updated:** 2024-10-03

## Collaborators

- [object Object]
- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT02960763

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT02960763, "Optimizing Outcomes of Treatment-Resistant Depression in Older Adults". Retrieved via AI Analytics 2026-06-02 from https://api.ai-analytics.org/clinical/NCT02960763. Licensed CC0.

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