# High-Intensity vs Low-Intensity NPPV in Patients With an AECOPD: The HAPPEN Trial

> **NCT02985918** · NA · TERMINATED · sponsor: **Beijing Chao Yang Hospital** · enrollment: 300 (actual)

## Conditions studied

- Acute Exacerbation of Chronic Obstructive Pulmonary Disease

## Interventions

- **DEVICE:** High-intensity NPPV
- **DEVICE:** Low-intensity NPPV

## Key facts

- **NCT ID:** NCT02985918
- **Lead sponsor:** Beijing Chao Yang Hospital
- **Sponsor class:** OTHER
- **Phase:** NA
- **Study type:** INTERVENTIONAL
- **Status:** TERMINATED
- **Start date:** 2019-01-03
- **Primary completion:** 2022-01-31
- **Final completion:** 2022-04-22
- **Target enrollment:** 300 (ACTUAL)
- **Why stopped:** The trial has been terminated by the DSMB and the trial steering committee, based on the interim analysis results and the impracticality of continuing the trial in the context of the coronavirus disease 2019 (COVID-19) pandemic.
- **Last updated:** 2024-02-07


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT02985918

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT02985918, "High-Intensity vs Low-Intensity NPPV in Patients With an AECOPD: The HAPPEN Trial". Retrieved via AI Analytics 2026-06-09 from https://api.ai-analytics.org/clinical/NCT02985918. Licensed CC0.

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