A Vaccine (VSV-hIFNβ-NIS) With or Without Cyclophosphamide and Combinations of Ipilimumab, Nivolumab, and Cemiplimab in Treating Relapsed or Refractory Multiple Myeloma, Acute Myeloid Leukemia or Lymphoma
Conditions
- B-Cell Non-Hodgkin Lymphoma
- Histiocytic and Dendritic Cell Neoplasm
- Myelodysplastic Syndrome
- Previously Treated Myelodysplastic Syndrome
- Recurrent Adult Acute Myeloid Leukemia
- Recurrent Anaplastic Large Cell Lymphoma
- Recurrent Angioimmunoblastic T-Cell Lymphoma
- Recurrent Mycosis Fungoides
- Recurrent Plasma Cell Myeloma
- Recurrent Primary Cutaneous T-Cell Non-Hodgkin Lymphoma
- Recurrent T-Cell Non-Hodgkin Lymphoma
- Refractory Acute Myeloid Leukemia
- Refractory Anaplastic Large Cell Lymphoma
- Refractory Angioimmunoblastic T-Cell Lymphoma
- Refractory Mycosis Fungoides
- Refractory Peripheral T-Cell Lymphoma, Not Otherwise Specified
- Refractory Plasma Cell Myeloma
- Refractory Primary Cutaneous T-Cell Non-Hodgkin Lymphoma
- Refractory T-Cell Non-Hodgkin Lymphoma
Interventions
- PROCEDURE: Biopsy Procedure
- PROCEDURE: Biospecimen Collection
- PROCEDURE: Bone Marrow Biopsy
- PROCEDURE: Computed Tomography
- DRUG: Cyclophosphamide
- PROCEDURE: Positron Emission Tomography
- BIOLOGICAL: Recombinant Vesicular Stomatitis Virus-expressing Human Interferon Beta and Sodium-Iodide Symporter
- PROCEDURE: Single Photon Emission Computed Tomography
- BIOLOGICAL: Cemiplimab
- DRUG: Ruxolitinib
- BIOLOGICAL: ipilimumab
- BIOLOGICAL: Nivolumab
- PROCEDURE: Multigated Acquisition Scan
- PROCEDURE: Echocardiography Test
- PROCEDURE: Bone Marrow Aspiration
Sponsor
Mayo Clinic
Collaborators