# Molecular Investigation of Genetic Factors in CArDiovascular Diseases Using an BIOresource of Healthy Volunteers

> **NCT03038750** · — · TERMINATED · sponsor: **Cambridge University Hospitals NHS Foundation Trust** · enrollment: 74 (actual)

## Conditions studied

- Cardiovascular Diseases

## Interventions

- **OTHER:** Eligibility and lifestyle restrictions check.
- **OTHER:** Medical history, demographic and lifestyle factors
- **OTHER:** Anthropometric measurements: height, weight, and body fat
- **OTHER:** Blood pressure and heart rate
- **OTHER:** Forearm blood flow: Visit 1 (EDNRA)
- **OTHER:** Forearm blood flow: Visit 2 (EDNRA)
- **OTHER:** Blood biochemistry (PNPLA3)
- **OTHER:** Blood EPCR function (PROCR)
- **OTHER:** Blood platelet coagulation and function (PROCR)
- **OTHER:** Blood endothelial permeability (PROCR)
- **OTHER:** Blood leukocyte-endothelium adhesion (PROCR)
- **OTHER:** Baseline Venepuncture (PNPLA3, Visit 1)
- **OTHER:** Deuterium water - Loading dose 1 (PNPLA3, Visit 1)
- **OTHER:** Deuterium water - Loading dose 2 (PNPLA3, Visit 1)
- **OTHER:** Energy-balanced dinner (PNPLA3, Visit 1)
- **OTHER:** Fasting venepuncture (PNPLA3, Visit 2)
- **OTHER:** Deuterium water - Maintenance dose (PNPLA3, Visit 2)
- **OTHER:** Consumption of high carbohydrate meal (PNPLA3, Visit 2)
- **OTHER:** Postprandial Venepuncture (PNPLA3, Visit 2)
- **OTHER:** Venepuncture (PROCR)

## Key facts

- **NCT ID:** NCT03038750
- **Lead sponsor:** Cambridge University Hospitals NHS Foundation Trust
- **Sponsor class:** OTHER
- **Phase:** —
- **Study type:** OBSERVATIONAL
- **Status:** TERMINATED
- **Start date:** 2017-08-14
- **Primary completion:** 2023-06-06
- **Final completion:** 2023-06-06
- **Target enrollment:** 74 (ACTUAL)
- **Why stopped:** The delay due to suspending the study due to covid, subsequent problems in synthesis, supply and yield of BQ123, prevented completion of the study as planned.
- **Last updated:** 2024-02-02

## Collaborators

- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT03038750

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT03038750, "Molecular Investigation of Genetic Factors in CArDiovascular Diseases Using an BIOresource of Healthy Volunteers". Retrieved via AI Analytics 2026-06-02 from https://api.ai-analytics.org/clinical/NCT03038750. Licensed CC0.

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