# Pentoxifylline and Tocopherol (PENTO) in the Treatment of Medication-related Osteonecrosis of the Jaw (MRONJ)

> **NCT03040778** · PHASE3 · ACTIVE_NOT_RECRUITING · sponsor: **University of Washington** · enrollment: 100 (estimated)

## Conditions studied

- Medication-related Osteonecrosis of the Jaw
- Bisphosphonate-related Osteonecrosis of the Jaw
- Avascular Necrosis

## Interventions

- **DRUG:** Pentoxifylline
- **DRUG:** Placebo
- **DRUG:** Tocopherol

## Key facts

- **NCT ID:** NCT03040778
- **Lead sponsor:** University of Washington
- **Sponsor class:** OTHER
- **Phase:** PHASE3
- **Study type:** INTERVENTIONAL
- **Status:** ACTIVE_NOT_RECRUITING
- **Start date:** 2018-04-01
- **Primary completion:** 2026-05
- **Final completion:** 2026-06-30
- **Target enrollment:** 100 (ESTIMATED)
- **Last updated:** 2026-04-29

## Collaborators

- [object Object]
- [object Object]
- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT03040778

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT03040778, "Pentoxifylline and Tocopherol (PENTO) in the Treatment of Medication-related Osteonecrosis of the Jaw (MRONJ)". Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/clinical/NCT03040778. Licensed CC0.

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