# Active Surveillance, Bleomycin, Etoposide, Carboplatin or Cisplatin in Treating Pediatric and Adult Patients With Germ Cell Tumors

> **NCT03067181** · PHASE3 · RECRUITING · sponsor: **Children's Oncology Group** · enrollment: 1780 (estimated)

## Conditions studied

- Childhood Extracranial Germ Cell Tumor
- Extragonadal Embryonal Carcinoma
- Germ Cell Tumor
- Malignant Germ Cell Tumor
- Malignant Ovarian Teratoma
- Stage I Ovarian Choriocarcinoma
- Stage I Ovarian Embryonal Carcinoma AJCC v6 and v7
- Stage I Ovarian Yolk Sac Tumor AJCC v6 and v7
- Stage I Testicular Choriocarcinoma AJCC v6 and v7
- Stage I Testicular Embryonal Carcinoma AJCC v6 and v7
- Stage I Testicular Seminoma AJCC v6 and v7
- Stage I Testicular Yolk Sac Tumor AJCC v6 and v7
- Stage II Ovarian Choriocarcinoma
- Stage II Ovarian Embryonal Carcinoma AJCC v6 and v7
- Stage II Ovarian Yolk Sac Tumor AJCC v6 and v7
- Stage II Testicular Choriocarcinoma AJCC v6 and v7
- Stage II Testicular Embryonal Carcinoma AJCC v6 and v7
- Stage II Testicular Yolk Sac Tumor AJCC v6 and v7
- Stage III Ovarian Choriocarcinoma
- Stage III Ovarian Embryonal Carcinoma AJCC v6 and v7
- Stage III Ovarian Yolk Sac Tumor AJCC v6 and v7
- Stage III Testicular Choriocarcinoma AJCC v6 and v7
- Stage III Testicular Embryonal Carcinoma AJCC v6 and v7
- Stage III Testicular Yolk Sac Tumor AJCC v6 and v7
- Stage IV Ovarian Choriocarcinoma
- Stage IV Ovarian Embryonal Carcinoma AJCC v6 and v7
- Stage IV Ovarian Yolk Sac Tumor AJCC v6 and v7
- Testicular Mixed Choriocarcinoma and Embryonal Carcinoma
- Testicular Mixed Choriocarcinoma and Teratoma
- Testicular Mixed Choriocarcinoma and Yolk Sac Tumor

## Interventions

- **OTHER:** Best Practice
- **PROCEDURE:** Biopsy Procedure
- **PROCEDURE:** Biospecimen Collection
- **BIOLOGICAL:** Bleomycin Sulfate
- **DRUG:** Carboplatin
- **DRUG:** Cisplatin
- **PROCEDURE:** Computed Tomography
- **DRUG:** Etoposide
- **PROCEDURE:** Magnetic Resonance Imaging
- **PROCEDURE:** Pulmonary Function Test
- **OTHER:** Questionnaire Administration

## Key facts

- **NCT ID:** NCT03067181
- **Lead sponsor:** Children's Oncology Group
- **Sponsor class:** NETWORK
- **Phase:** PHASE3
- **Study type:** INTERVENTIONAL
- **Status:** RECRUITING
- **Start date:** 2017-05-25
- **Primary completion:** 2027-06-30
- **Final completion:** 2027-06-30
- **Target enrollment:** 1780 (ESTIMATED)
- **Last updated:** 2026-05-05

## Collaborators

- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT03067181

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT03067181, "Active Surveillance, Bleomycin, Etoposide, Carboplatin or Cisplatin in Treating Pediatric and Adult Patients With Germ Cell Tumors". Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/clinical/NCT03067181. Licensed CC0.

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