# Carbon Dioxide Surgical Field Flooding and Aortic No-touch Off-pump Coronary Artery Bypass Grafting to Reduce Neurological Injuries After Surgical Coronary Revascularization (CANON): a Randomised, Controlled, Investigator and Patient Blinded Single Center Superiority Trial With Three Parallel Arms.

> **NCT03074604** · NA · COMPLETED · sponsor: **Collegium Medicum w Bydgoszczy** · enrollment: 192 (actual)

## Conditions studied

- Neurological Injury
- Stroke
- Postoperative Cognitive Dysfunction
- Postoperative Delirium
- Coronary Artery Disease
- Coronary Artery Bypass Surgery
- Off-Pump Coronary Artery Bypass

## Interventions

- **PROCEDURE:** aortic no-touch OPCABG
- **PROCEDURE:** OPCABG with partial clamp applying carbon dioxide
- **PROCEDURE:** OPCABG with partial clamp

## Key facts

- **NCT ID:** NCT03074604
- **Lead sponsor:** Collegium Medicum w Bydgoszczy
- **Sponsor class:** OTHER
- **Phase:** NA
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2017-02-28
- **Primary completion:** 2018-07-01
- **Final completion:** 2018-07-01
- **Target enrollment:** 192 (ACTUAL)
- **Last updated:** 2020-02-05


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT03074604

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT03074604, "Carbon Dioxide Surgical Field Flooding and Aortic No-touch Off-pump Coronary Artery Bypass Grafting to Reduce Neurological Injuries After Surgical Coronary Revascularization (CANON): a Randomised, Controlled, Investigator and Patient Blinded Single Center Superiority Trial With Three Parallel Arms.". Retrieved via AI Analytics 2026-06-02 from https://api.ai-analytics.org/clinical/NCT03074604. Licensed CC0.

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