# BIO4 Clinical Case Study: Cervical Spine

> **NCT03077204** · PHASE4 · COMPLETED · sponsor: **Seton Healthcare Family** · enrollment: 20 (actual)

## Conditions studied

- Degenerative Disc Disease
- Trauma (Including Fractures)
- Spondylolisthesis

## Interventions

- **BIOLOGICAL:** 1 or 2-Level ACDF utilizing BIO4 with Bio AVS Cervical Allograft (with graft window).
- **DEVICE:** Aviator Anterior Cervical Plating System

## Key facts

- **NCT ID:** NCT03077204
- **Lead sponsor:** Seton Healthcare Family
- **Sponsor class:** OTHER
- **Phase:** PHASE4
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2017-04-06
- **Primary completion:** 2020-01-30
- **Final completion:** 2020-01-30
- **Target enrollment:** 20 (ACTUAL)
- **Last updated:** 2022-01-14


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT03077204

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT03077204, "BIO4 Clinical Case Study: Cervical Spine". Retrieved via AI Analytics 2026-06-02 from https://api.ai-analytics.org/clinical/NCT03077204. Licensed CC0.

---

*[Clinical trials dataset](/datasets/clinical-trials) · CC0 1.0*