# Antipruritic Effect of Topical Ketamine, Amitriptyline, and Lidocaine

> **NCT03096444** · PHASE2 · TERMINATED · sponsor: **Gil Yosipovitch** · enrollment: 13 (actual)

## Conditions studied

- Pruritus

## Interventions

- **DRUG:** Ketamine Hydrochloride
- **DRUG:** Amitriptyline Hydrochloride
- **DRUG:** Lidocaine Hydrochloride
- **COMBINATION_PRODUCT:** Ketamine hydrochloride, Amitriptyline hydrochloride, and Lidocaine hydrochloride
- **DRUG:** Lipoderm Cream

## Key facts

- **NCT ID:** NCT03096444
- **Lead sponsor:** Gil Yosipovitch
- **Sponsor class:** OTHER
- **Phase:** PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** TERMINATED
- **Start date:** 2017-05-23
- **Primary completion:** 2017-07-19
- **Final completion:** 2017-07-21
- **Target enrollment:** 13 (ACTUAL)
- **Why stopped:** Efficacy was not seen after interim analysis
- **Last updated:** 2019-07-02


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT03096444

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT03096444, "Antipruritic Effect of Topical Ketamine, Amitriptyline, and Lidocaine". Retrieved via AI Analytics 2026-06-15 from https://api.ai-analytics.org/clinical/NCT03096444. Licensed CC0.

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