Neratinib and Paclitaxel With or Without Pertuzumab and Trastuzumab Before Combination Chemotherapy in Treating Patients With Metastatic or Locally Advanced Breast Cancer

NCT03101748 · clinicaltrials.gov ↗

PHASE1,PHASE2

Phase

TERMINATED

Status

34

Enrollment

OTHER

Sponsor class

Stopped \<75% accrued

Conditions

Breast Inflammatory Carcinoma
Locally Advanced Breast Carcinoma
Metastatic Breast Carcinoma
Stage III Breast Cancer AJCC v7
Stage IIIA Breast Cancer AJCC v7
Stage IIIB Breast Cancer AJCC v7
Stage IIIC Breast Cancer AJCC v7
Stage IV Breast Cancer AJCC v6 and v7

Interventions

DRUG: Cyclophosphamide
DRUG: Doxorubicin
OTHER: Laboratory Biomarker Analysis
DRUG: Neratinib
DRUG: Paclitaxel
BIOLOGICAL: Pertuzumab
BIOLOGICAL: Trastuzumab

Sponsor

M.D. Anderson Cancer Center

Collaborators

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