# Efficacy and Safety of IONIS-PKKRx for Preventive Treatment of Chronic Migraine

> **NCT03108469** · PHASE2 · COMPLETED · sponsor: **Smith, Timothy R., M.D.** · enrollment: 30 (actual)

## Conditions studied

- Chronic Migraine

## Interventions

- **DRUG:** IONIS-PKKRx (ISIS 546254)
- **OTHER:** Placebo

## Key facts

- **NCT ID:** NCT03108469
- **Lead sponsor:** Smith, Timothy R., M.D.
- **Sponsor class:** INDIV
- **Phase:** PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2017-08-01
- **Primary completion:** 2019-04-26
- **Final completion:** 2019-04-26
- **Target enrollment:** 30 (ACTUAL)
- **Last updated:** 2020-02-12

## Collaborators

- [object Object]
- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT03108469

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT03108469, "Efficacy and Safety of IONIS-PKKRx for Preventive Treatment of Chronic Migraine". Retrieved via AI Analytics 2026-05-31 from https://api.ai-analytics.org/clinical/NCT03108469. Licensed CC0.

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