# Metformin Hydrochloride in Affecting Cytokines and Exosomes in Patients With Head and Neck Cancer

> **NCT03109873** · EARLY_PHASE1 · COMPLETED · sponsor: **Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University** · enrollment: 9 (actual)

## Conditions studied

- Larynx
- Lip
- Oral Cavity
- Pharynx

## Interventions

- **RADIATION:** External Beam Radiation Therapy
- **DRUG:** Metformin Hydrochloride
- **OTHER:** Placebo

## Key facts

- **NCT ID:** NCT03109873
- **Lead sponsor:** Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University
- **Sponsor class:** OTHER
- **Phase:** EARLY_PHASE1
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2017-01-05
- **Primary completion:** 2020-07-31
- **Final completion:** 2020-07-31
- **Target enrollment:** 9 (ACTUAL)
- **Last updated:** 2025-04-30


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT03109873

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT03109873, "Metformin Hydrochloride in Affecting Cytokines and Exosomes in Patients With Head and Neck Cancer". Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/clinical/NCT03109873. Licensed CC0.

---

*[Clinical trials dataset](/datasets/clinical-trials) · CC0 1.0*