Testing the Addition of 131I-MIBG or Lorlatinib to Intensive Therapy in People With High-Risk Neuroblastoma (NBL)

NCT03126916 · clinicaltrials.gov ↗

PHASE3

Phase

RECRUITING

Status

750

Enrollment

NETWORK

Sponsor class

Conditions

Ganglioneuroblastoma
Ganglioneuroblastoma, Nodular
Neuroblastoma

Interventions

PROCEDURE: Autologous Hematopoietic Stem Cell Transplantation
PROCEDURE: Biospecimen Collection
PROCEDURE: Bone Marrow Aspiration and Biopsy
DRUG: Busulfan
DRUG: Carboplatin
DRUG: Cisplatin
PROCEDURE: Computed Tomography
DRUG: Cyclophosphamide
DRUG: Dexrazoxane Hydrochloride
BIOLOGICAL: Dinutuximab
DRUG: Doxorubicin Hydrochloride
PROCEDURE: Echocardiography Test
DRUG: Etoposide Phosphate
RADIATION: External Beam Radiation Therapy
RADIATION: Iobenguane I-123
RADIATION: Iobenguane I-131
DRUG: Isotretinoin
DRUG: Lorlatinib
PROCEDURE: Magnetic Resonance Imaging
DRUG: Melphalan Hydrochloride

Sponsor

Children's Oncology Group

Collaborators

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