# High Dose Cyclophosphamide, Tacrolimus, and Mycophenolate Mofetil in Preventing Graft Versus Host Disease in Patients With Hematological Malignancies Undergoing Myeloablative or Reduced Intensity Donor Stem Cell Transplant

> **NCT03128359** · PHASE2 · COMPLETED · sponsor: **City of Hope Medical Center** · enrollment: 38 (actual)

## Conditions studied

- Acute Leukemia
- Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma
- Chronic Myelogenous Leukemia, BCR-ABL1 Positive
- Diffuse Large B-Cell Lymphoma
- Follicular Lymphoma
- Graft Versus Host Disease
- Hodgkin Lymphoma
- Mantle Cell Lymphoma
- Marginal Zone Lymphoma
- Myelodysplastic Syndrome
- Myeloproliferative Neoplasm
- Recurrent Acute Myeloid Leukemia With Myelodysplasia-Related Changes
- Recurrent Plasma Cell Myeloma
- Refractory Plasma Cell Myeloma
- Secondary Myelodysplastic Syndrome

## Interventions

- **DRUG:** Busulfan
- **DRUG:** Cyclophosphamide
- **DRUG:** Fludarabine Phosphate
- **PROCEDURE:** Hematopoietic Cell Transplantation
- **OTHER:** Laboratory Biomarker Analysis
- **DRUG:** Melphalan Hydrochloride
- **DRUG:** Mycophenolate Mofetil
- **PROCEDURE:** Peripheral Blood Stem Cell Transplantation
- **OTHER:** Quality-of-Life Assessment
- **DRUG:** Tacrolimus
- **RADIATION:** Total-Body Irradiation

## Key facts

- **NCT ID:** NCT03128359
- **Lead sponsor:** City of Hope Medical Center
- **Sponsor class:** OTHER
- **Phase:** PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2017-05-30
- **Primary completion:** 2020-08-01
- **Final completion:** 2021-09-15
- **Target enrollment:** 38 (ACTUAL)
- **Last updated:** 2024-01-09

## Collaborators

- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT03128359

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT03128359, "High Dose Cyclophosphamide, Tacrolimus, and Mycophenolate Mofetil in Preventing Graft Versus Host Disease in Patients With Hematological Malignancies Undergoing Myeloablative or Reduced Intensity Donor Stem Cell Transplant". Retrieved via AI Analytics 2026-05-28 from https://api.ai-analytics.org/clinical/NCT03128359. Licensed CC0.

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