Targeted Therapy Directed by Genetic Testing in Treating Pediatric Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphomas, or Histiocytic Disorders (The Pediatric MATCH Screening Trial)
ACTIVE_NOT_RECRUITING
Status
Conditions
- Advanced Malignant Solid Neoplasm
- Ann Arbor Stage III Non-Hodgkin Lymphoma
- Ann Arbor Stage IV Non-Hodgkin Lymphoma
- Histiocytic Sarcoma
- Juvenile Xanthogranuloma
- Langerhans Cell Histiocytosis
- Malignant Glioma
- Recurrent Childhood Rhabdomyosarcoma
- Recurrent Ependymoma
- Recurrent Ewing Sarcoma
- Recurrent Glioma
- Recurrent Hepatoblastoma
- Recurrent Langerhans Cell Histiocytosis
- Recurrent Malignant Germ Cell Tumor
- Recurrent Malignant Solid Neoplasm
- Recurrent Medulloblastoma
- Recurrent Neuroblastoma
- Recurrent Non-Hodgkin Lymphoma
- Recurrent Osteosarcoma
- Recurrent Peripheral Primitive Neuroectodermal Tumor
- Recurrent Primary Central Nervous System Neoplasm
- Recurrent Rhabdoid Tumor
- Recurrent Soft Tissue Sarcoma
- Refractory Ewing Sarcoma
- Refractory Glioma
- Refractory Hepatoblastoma
- Refractory Langerhans Cell Histiocytosis
- Refractory Malignant Germ Cell Tumor
- Refractory Malignant Solid Neoplasm
- Refractory Medulloblastoma
- Refractory Neuroblastoma
- Refractory Non-Hodgkin Lymphoma
- Refractory Osteosarcoma
- Refractory Peripheral Primitive Neuroectodermal Tumor
- Refractory Primary Central Nervous System Neoplasm
- Refractory Rhabdoid Tumor
- Refractory Rhabdomyosarcoma
- Rhabdoid Tumor
- Stage III Osteosarcoma AJCC v7
- Stage III Soft Tissue Sarcoma AJCC v7
- Stage IV Osteosarcoma AJCC v7
- Stage IV Soft Tissue Sarcoma AJCC v7
- Stage IVA Osteosarcoma AJCC v7
- Stage IVB Osteosarcoma AJCC v7
- Wilms Tumor
Interventions
- PROCEDURE: Biopsy Procedure
- PROCEDURE: Biospecimen Collection
- PROCEDURE: Bone Marrow Aspiration and Biopsy
- PROCEDURE: Bone Scan
- PROCEDURE: Computed Tomography
- DRUG: Ensartinib
- DRUG: Erdafitinib
- DRUG: Ivosidenib
- OTHER: Laboratory Biomarker Analysis
- DRUG: Larotrectinib Sulfate
- PROCEDURE: Magnetic Resonance Imaging
- PROCEDURE: Mutation Carrier Screening
- DRUG: Olaparib
- DRUG: Palbociclib
- OTHER: Pharmacological Study
- PROCEDURE: Positron Emission Tomography
- PROCEDURE: Radionuclide Imaging
- DRUG: Samotolisib
- DRUG: Selpercatinib
- DRUG: Selumetinib Sulfate
- DRUG: Tazemetostat
- DRUG: Tipifarnib
- DRUG: Ulixertinib
- DRUG: Vemurafenib
- PROCEDURE: X-Ray Imaging
Sponsor
National Cancer Institute (NCI)