TVB-2640 and Trastuzumab With Paclitaxel or Endocrine Therapy for Treatment of HER2 Positive Metastatic Breast Cancer

NCT03179904 · clinicaltrials.gov ↗

PHASE2

Phase

ACTIVE_NOT_RECRUITING

Status

17

Enrollment

OTHER

Sponsor class

Conditions

Advanced Breast Carcinoma
HER2-Positive Breast Carcinoma
Anatomic Stage III Breast Cancer AJCC v8
Anatomic Stage IV Breast Cancer AJCC v8
HER2-positive Breast Cancer

Interventions

DRUG: Anastrozole
DRUG: Denifanstat
DRUG: Exemestane
DRUG: Fulvestrant
PROCEDURE: Echocardiography
DRUG: Letrozole
DRUG: Paclitaxel
BIOLOGICAL: Trastuzumab
PROCEDURE: Computed Tomography
PROCEDURE: Magnetic Resonance Imaging
PROCEDURE: Biospecimen Collection
PROCEDURE: Biopsy

Sponsor

Mayo Clinic