# Proton Beam or Intensity-Modulated Radiation Therapy in Preserving Brain Function in Patients With IDH Mutant Grade II or III Glioma

> **NCT03180502** · PHASE2 · ACTIVE_NOT_RECRUITING · sponsor: **NRG Oncology** · enrollment: 120 (estimated)

## Conditions studied

- Anaplastic Astrocytoma
- Anaplastic Oligoastrocytoma
- Anaplastic Oligodendroglioma
- Diffuse Astrocytoma
- Glioma
- Oligoastrocytoma
- Oligodendroglioma
- WHO Grade 3 Glioma

## Interventions

- **PROCEDURE:** Biospecimen Collection
- **RADIATION:** Intensity-Modulated Radiation Therapy
- **OTHER:** Laboratory Biomarker Analysis
- **PROCEDURE:** Magnetic Resonance Imaging
- **RADIATION:** Proton Beam Radiation Therapy
- **OTHER:** Quality-of-Life Assessment
- **OTHER:** Questionnaire Administration
- **DRUG:** Temozolomide

## Key facts

- **NCT ID:** NCT03180502
- **Lead sponsor:** NRG Oncology
- **Sponsor class:** OTHER
- **Phase:** PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** ACTIVE_NOT_RECRUITING
- **Start date:** 2018-01-23
- **Primary completion:** 2026-06-01
- **Final completion:** 2027-06-01
- **Target enrollment:** 120 (ESTIMATED)
- **Last updated:** 2026-05-07

## Collaborators

- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT03180502

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT03180502, "Proton Beam or Intensity-Modulated Radiation Therapy in Preserving Brain Function in Patients With IDH Mutant Grade II or III Glioma". Retrieved via AI Analytics 2026-05-20 from https://api.ai-analytics.org/clinical/NCT03180502. Licensed CC0.

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