# Treatment of Fatigue With Methylphenidate, Modafinil and Amantadine in Multiple Sclerosis

> **NCT03185065** · PHASE3 · COMPLETED · sponsor: **Johns Hopkins University** · enrollment: 141 (actual)

## Conditions studied

- Fatigue in Multiple Sclerosis

## Interventions

- **DRUG:** Amantadine
- **DRUG:** Modafinil
- **DRUG:** Methylphenidate
- **DRUG:** Placebos

## Key facts

- **NCT ID:** NCT03185065
- **Lead sponsor:** Johns Hopkins University
- **Sponsor class:** OTHER
- **Phase:** PHASE3
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2017-10-04
- **Primary completion:** 2019-11-21
- **Final completion:** 2019-11-21
- **Target enrollment:** 141 (ACTUAL)
- **Last updated:** 2020-10-20

## Collaborators

- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT03185065

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT03185065, "Treatment of Fatigue With Methylphenidate, Modafinil and Amantadine in Multiple Sclerosis". Retrieved via AI Analytics 2026-05-21 from https://api.ai-analytics.org/clinical/NCT03185065. Licensed CC0.

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