# The preSPG4 Study - Studying the Prodromal and Early Phase of SPG4

> **NCT03206190** · NA · RECRUITING · sponsor: **University Hospital Tuebingen** · enrollment: 200 (estimated)

## Conditions studied

- Hereditary Spastic Paraplegia
- Hereditary, Spastic Paraplegia, Autosomal Dominant

## Interventions

- **OTHER:** SPRS Score and clinical signs
- **BEHAVIORAL:** Cognition Testing using CANTAB
- **DIAGNOSTIC_TEST:** Lumbar Puncture and blood draw
- **DIAGNOSTIC_TEST:** MRI
- **DIAGNOSTIC_TEST:** Electrophysiology
- **DIAGNOSTIC_TEST:** Testing functional performance
- **DIAGNOSTIC_TEST:** Non motor symptoms

## Key facts

- **NCT ID:** NCT03206190
- **Lead sponsor:** University Hospital Tuebingen
- **Sponsor class:** OTHER
- **Phase:** NA
- **Study type:** INTERVENTIONAL
- **Status:** RECRUITING
- **Start date:** 2018-07-01
- **Primary completion:** 2029-12
- **Final completion:** 2031-12
- **Target enrollment:** 200 (ESTIMATED)
- **Last updated:** 2022-08-23


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT03206190

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT03206190, "The preSPG4 Study - Studying the Prodromal and Early Phase of SPG4". Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/clinical/NCT03206190. Licensed CC0.

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