# Treatment Protocol of the NHL-BFM and the NOPHO Study Groups for Mature Aggressive B-cell Lymphoma and Leukemia in Children and Adolescents

> **NCT03206671** · PHASE3 · ACTIVE_NOT_RECRUITING · sponsor: **University Hospital Muenster** · enrollment: 650 (estimated)

## Conditions studied

- Mature B-cell Non-Hodgkin Lymphoma

## Interventions

- **DRUG:** Rituximab window
- **DRUG:** Additional doses of Rituximab
- **DRUG:** Cyclophosphamide
- **DRUG:** Cytarabine
- **DRUG:** Dexamethasone
- **DRUG:** Doxorubicin hydrochloride
- **DRUG:** Vindesine Sulfate
- **DRUG:** Etoposide
- **DRUG:** Ifosfamide
- **DRUG:** Methotrexate
- **DRUG:** Prednisolone
- **DRUG:** Vincristine

## Key facts

- **NCT ID:** NCT03206671
- **Lead sponsor:** University Hospital Muenster
- **Sponsor class:** OTHER
- **Phase:** PHASE3
- **Study type:** INTERVENTIONAL
- **Status:** ACTIVE_NOT_RECRUITING
- **Start date:** 2017-08-03
- **Primary completion:** 2027-06
- **Final completion:** 2027-06
- **Target enrollment:** 650 (ESTIMATED)
- **Last updated:** 2026-04-30

## Collaborators

- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT03206671

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT03206671, "Treatment Protocol of the NHL-BFM and the NOPHO Study Groups for Mature Aggressive B-cell Lymphoma and Leukemia in Children and Adolescents". Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/clinical/NCT03206671. Licensed CC0.

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