# Nivolumab or Expectant Observation Following Ipilimumab, Nivolumab, and Surgery in Treating Patients With High Risk Localized, Locoregionally Advanced, or Recurrent Mucosal Melanoma

> **NCT03220009** · PHASE2 · WITHDRAWN · sponsor: **National Cancer Institute (NCI)**

## Conditions studied

- Cervical Carcinoma
- Esophageal Carcinoma
- Mucosal Melanoma
- Mucosal Melanoma of the Head and Neck
- Oral Cavity Mucosal Melanoma
- Recurrent Melanoma
- Stage II Vulvar Cancer AJCC v7
- Stage III Vulvar Cancer AJCC v7
- Stage IIIA Vulvar Cancer AJCC v7
- Stage IIIB Vulvar Cancer AJCC v7
- Stage IIIC Vulvar Cancer AJCC v7
- Stage IV Oral Cavity Cancer AJCC v6 and v7
- Stage IV Vulvar Cancer AJCC v7
- Stage IVA Oral Cavity Cancer AJCC v6 and v7
- Stage IVB Oral Cavity Cancer AJCC v6 and v7
- Stage IVC Oral Cavity Cancer AJCC v6 and v7
- Vaginal Carcinoma

## Interventions

- **PROCEDURE:** Conventional Surgery
- **BIOLOGICAL:** Ipilimumab
- **OTHER:** Laboratory Biomarker Analysis
- **BIOLOGICAL:** Nivolumab
- **OTHER:** Patient Observation
- **RADIATION:** Radiation Therapy

## Key facts

- **NCT ID:** NCT03220009
- **Lead sponsor:** National Cancer Institute (NCI)
- **Sponsor class:** NIH
- **Phase:** PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** WITHDRAWN
- **Start date:** 2017-11-03
- **Primary completion:** 2021-07-01
- **Final completion:** 2021-07-01
- **Target enrollment:** 0 (ACTUAL)
- **Why stopped:** The study was never approved by CTEP neither was it ever activated
- **Last updated:** 2018-10-03


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT03220009

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT03220009, "Nivolumab or Expectant Observation Following Ipilimumab, Nivolumab, and Surgery in Treating Patients With High Risk Localized, Locoregionally Advanced, or Recurrent Mucosal Melanoma". Retrieved via AI Analytics 2026-05-28 from https://api.ai-analytics.org/clinical/NCT03220009. Licensed CC0.

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