# Effect of Duloxetine on Opioid Use After Total Knee Arthroplasty

> **NCT03271151** · PHASE4 · COMPLETED · sponsor: **Hospital for Special Surgery, New York** · enrollment: 160 (actual)

## Conditions studied

- Joint Disease
- Pain, Acute
- Pain, Chronic

## Interventions

- **DRUG:** Cymbalta
- **OTHER:** Placebo

## Key facts

- **NCT ID:** NCT03271151
- **Lead sponsor:** Hospital for Special Surgery, New York
- **Sponsor class:** OTHER
- **Phase:** PHASE4
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2017-09-28
- **Primary completion:** 2020-12-03
- **Final completion:** 2021-02-19
- **Target enrollment:** 160 (ACTUAL)
- **Last updated:** 2024-12-27


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT03271151

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT03271151, "Effect of Duloxetine on Opioid Use After Total Knee Arthroplasty". Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/clinical/NCT03271151. Licensed CC0.

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*[Clinical trials dataset](/datasets/clinical-trials) · CC0 1.0*