# INvestigating the Lowest Threshold of Vascular bENefits From LDL Lowering With a PCSK9 InhibiTor in healthY Volunteers

> **NCT03273972** · NA · COMPLETED · sponsor: **Cambridge University Hospitals NHS Foundation Trust** · enrollment: 30 (actual)

## Conditions studied

- Atherosclerosis
- Cardiovascular Diseases

## Interventions

- **OTHER:** Written Informed Consent
- **OTHER:** Inclusion/Exclusion check
- **OTHER:** Full Clinical Chemistry and Haematology Bloods
- **OTHER:** Serum sample for systemic markers and lipid sub-fractions
- **OTHER:** Pregnancy Test
- **OTHER:** 12 Lead ECG
- **OTHER:** Blood Pressure and Heart Rate
- **OTHER:** Arterial Stiffness
- **OTHER:** Central Haemodynamics
- **OTHER:** Carotid Intima Media Thickness
- **OTHER:** Forearm blood flow studies
- **OTHER:** Concomitant medication check
- **OTHER:** Medication compliance check (Pill count)
- **OTHER:** Physical examination
- **OTHER:** Medical history
- **OTHER:** AE/SAE review & reporting
- **DRUG:** Dosing

## Key facts

- **NCT ID:** NCT03273972
- **Lead sponsor:** Cambridge University Hospitals NHS Foundation Trust
- **Sponsor class:** OTHER
- **Phase:** NA
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2017-09-07
- **Primary completion:** 2018-10-10
- **Final completion:** 2018-10-10
- **Target enrollment:** 30 (ACTUAL)
- **Last updated:** 2023-07-27

## Collaborators

- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT03273972

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT03273972, "INvestigating the Lowest Threshold of Vascular bENefits From LDL Lowering With a PCSK9 InhibiTor in healthY Volunteers". Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/clinical/NCT03273972. Licensed CC0.

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