# Inhaled Nitrous Oxide for Treatment-Resistant Depression: Optimizing Dosing Strategies

> **NCT03283670** · PHASE2 · COMPLETED · sponsor: **Washington University School of Medicine** · enrollment: 24 (actual)

## Conditions studied

- Depressive Disorder, Major
- Depressive Disorder, Treatment-Resistant

## Interventions

- **DRUG:** Nitrous Oxide 25%
- **DRUG:** Nitrous Oxide 50%
- **DRUG:** Placebo Gas

## Key facts

- **NCT ID:** NCT03283670
- **Lead sponsor:** Washington University School of Medicine
- **Sponsor class:** OTHER
- **Phase:** PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2016-11-22
- **Primary completion:** 2020-02-18
- **Final completion:** 2020-02-18
- **Target enrollment:** 24 (ACTUAL)
- **Last updated:** 2022-04-04

## Collaborators

- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT03283670

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT03283670, "Inhaled Nitrous Oxide for Treatment-Resistant Depression: Optimizing Dosing Strategies". Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/clinical/NCT03283670. Licensed CC0.

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