Different Doses of Olaparib Given With Radium-223 in Men With Advanced Prostate Cancer With Bone Metastasis

NCT03317392 · clinicaltrials.gov ↗

PHASE1,PHASE2

Phase

ACTIVE_NOT_RECRUITING

Status

132

Enrollment

NIH

Sponsor class

Conditions

Castration-Resistant Prostate Carcinoma
Metastatic Prostate Adenocarcinoma
Stage IVB Prostate Cancer AJCC v8

Interventions

PROCEDURE: Biopsy Procedure
PROCEDURE: Biospecimen Collection
PROCEDURE: Computed Tomography
OTHER: Laboratory Biomarker Analysis
PROCEDURE: Magnetic Resonance Imaging
DRUG: Olaparib
OTHER: Quality-of-Life Assessment
RADIATION: Radium Ra 223 Dichloride

Sponsor

National Cancer Institute (NCI)