# A Study to Assess Effectiveness and Efficiency of VNS Therapy in Patients With Difficult to Treat Depression.

> **NCT03320304** · — · RECRUITING · sponsor: **LivaNova** · enrollment: 500 (estimated)

## Conditions studied

- Treatment Resistant Depression

## Interventions

- **DEVICE:** Vagal Nerve Simulation (VNS) Therapy

## Key facts

- **NCT ID:** NCT03320304
- **Lead sponsor:** LivaNova
- **Sponsor class:** INDUSTRY
- **Phase:** —
- **Study type:** OBSERVATIONAL
- **Status:** RECRUITING
- **Start date:** 2017-12-14
- **Primary completion:** 2029-12-01
- **Final completion:** 2031-12-01
- **Target enrollment:** 500 (ESTIMATED)
- **Last updated:** 2026-01-26


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT03320304

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT03320304, "A Study to Assess Effectiveness and Efficiency of VNS Therapy in Patients With Difficult to Treat Depression.". Retrieved via AI Analytics 2026-07-13 from https://api.ai-analytics.org/clinical/NCT03320304. Licensed CC0.

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