HA-1 T TCR T Cell Immunotherapy for the Treatment of Patients With Relapsed or Refractory Acute Leukemia After Donor Stem Cell Transplant

Conditions

• Juvenile Myelomonocytic Leukemia
• Recurrent Acute Biphenotypic Leukemia
• Recurrent Acute Undifferentiated Leukemia
• Recurrent Childhood Acute Lymphoblastic Leukemia
• Recurrent Childhood Acute Myeloid Leukemia
• Refractory Acute Lymphoblastic Leukemia
• Refractory Adult Acute Lymphoblastic Leukemia
• Blast Phase Chronic Myeloid Leukemia, BCR-ABL1 Positive
• Recurrent Blastic Plasmacytoid Dendritic Cell Neoplasm
• Recurrent Myelodysplastic Syndrome
• Refractory Blastic Plasmacytoid Dendritic Cell Neoplasm
• Refractory Myelodysplastic Syndrome
• Acute Undifferentiated Leukemia
• Mixed Phenotype Acute Leukemia
• Recurrent Chronic Myeloid Leukemia, BCR-ABL1 Positive
• Refractory Chronic Myeloid Leukemia, BCR-ABL1 Positive
• Recurrent Acute Lymphoblastic Leukemia
• Recurrent Acute Myeloid Leukemia
• Myelodysplastic Syndrome
• Acute Myeloid Leukemia
• Acute Lymphoblastic Leukemia
• Acute Biphenotypic Leukemia
• Chronic Myeloid Leukemia
• Chronic Myelomonocytic Leukemia
• Minimal Residual Disease
• Recurrent Chronic Myelomonocytic Leukemia
• Recurrent Mixed Phenotype Acute Leukemia
• Leukemia
• Chronic Myeloid Leukemia, BCR-ABL1 Positive

Interventions

• BIOLOGICAL: CD8+ and CD4+ Donor Memory T-cells-expressing HA1-Specific TCR
• PROCEDURE: Bone Marrow Aspiration
• PROCEDURE: Biospecimen Collection

Sponsor

Fred Hutchinson Cancer Center

Collaborators

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