# A Study Assessing the Efficacy and Safety of DE-127 Ophthalmic Solution in Subjects With Mild or Moderate Myopia (APPLE)

> **NCT03329638** · PHASE2 · COMPLETED · sponsor: **Santen Pharmaceutical Co., Ltd.** · enrollment: 99 (actual)

## Conditions studied

- Myopia

## Interventions

- **DRUG:** DE-127 Ophthalmic Solution low dose
- **DRUG:** DE-127 Ophthalmic Solution medium dose
- **DRUG:** DE-127 Ophthalmic Solution high dose
- **DRUG:** Placebo Ophthalmic Solution

## Key facts

- **NCT ID:** NCT03329638
- **Lead sponsor:** Santen Pharmaceutical Co., Ltd.
- **Sponsor class:** INDUSTRY
- **Phase:** PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2017-10-27
- **Primary completion:** 2019-09-12
- **Final completion:** 2020-04-09
- **Target enrollment:** 99 (ACTUAL)
- **Last updated:** 2020-08-26


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT03329638

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT03329638, "A Study Assessing the Efficacy and Safety of DE-127 Ophthalmic Solution in Subjects With Mild or Moderate Myopia (APPLE)". Retrieved via AI Analytics 2026-06-01 from https://api.ai-analytics.org/clinical/NCT03329638. Licensed CC0.

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