# A Trial of Validation and Restoration of Immune Dysfunction in Severe Infections and Sepsis

> **NCT03332225** · PHASE2 · COMPLETED · sponsor: **Hellenic Institute for the Study of Sepsis** · enrollment: 36 (actual)

## Conditions studied

- Sepsis
- Macrophage Activation Syndrome

## Interventions

- **DRUG:** Anakinra
- **DRUG:** Recombinant human interferon-gamma
- **DRUG:** Placebo

## Key facts

- **NCT ID:** NCT03332225
- **Lead sponsor:** Hellenic Institute for the Study of Sepsis
- **Sponsor class:** OTHER
- **Phase:** PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2017-12-15
- **Primary completion:** 2019-12-31
- **Final completion:** 2019-12-31
- **Target enrollment:** 36 (ACTUAL)
- **Last updated:** 2020-07-29


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT03332225

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT03332225, "A Trial of Validation and Restoration of Immune Dysfunction in Severe Infections and Sepsis". Retrieved via AI Analytics 2026-06-03 from https://api.ai-analytics.org/clinical/NCT03332225. Licensed CC0.

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