# Fludarabine Phosphate, Cyclophosphamide, Total Body Irradiation, and Donor Stem Cell Transplant in Treating Patients With Blood Cancer

> **NCT03333486** · PHASE2 · TERMINATED · sponsor: **Roswell Park Cancer Institute** · enrollment: 31 (actual)

## Conditions studied

- Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive
- Acute Leukemia in Remission
- Acute Lymphoblastic Leukemia
- Acute Myeloid Leukemia
- Acute Myeloid Leukemia With FLT3/ITD Mutation
- Acute Myeloid Leukemia With Gene Mutations
- Aplastic Anemia
- B-Cell Non-Hodgkin Lymphoma
- CD40 Ligand Deficiency
- Chronic Granulomatous Disease
- Chronic Leukemia in Remission
- Chronic Lymphocytic Leukemia
- Chronic Myelogenous Leukemia, BCR-ABL1 Positive
- Chronic Myelomonocytic Leukemia
- Chronic Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive
- Congenital Amegakaryocytic Thrombocytopenia
- Congenital Neutropenia
- Congenital Pure Red Cell Aplasia
- Glanzmann Thrombasthenia
- Immunodeficiency Syndrome
- Myelodysplastic Syndrome
- Myelofibrosis
- Myeloproliferative Neoplasm
- Paroxysmal Nocturnal Hemoglobinuria
- Plasma Cell Myeloma
- Polycythemia Vera
- Recurrent Non-Hodgkin Lymphoma
- Refractory Non-Hodgkin Lymphoma
- Secondary Acute Myeloid Leukemia
- Secondary Myelodysplastic Syndrome
- Severe Aplastic Anemia
- Shwachman-Diamond Syndrome
- Sickle Cell Disease
- T-Cell Non-Hodgkin Lymphoma
- Thalassemia
- Waldenstrom Macroglobulinemia
- Wiskott-Aldrich Syndrome

## Interventions

- **DRUG:** Cyclophosphamide
- **DRUG:** Fludarabine Phosphate
- **OTHER:** Laboratory Biomarker Analysis
- **PROCEDURE:** Peripheral Blood Stem Cell Transplantation
- **RADIATION:** Total-Body Irradiation

## Key facts

- **NCT ID:** NCT03333486
- **Lead sponsor:** Roswell Park Cancer Institute
- **Sponsor class:** OTHER
- **Phase:** PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** TERMINATED
- **Start date:** 2017-12-07
- **Primary completion:** 2023-08-28
- **Final completion:** 2023-08-28
- **Target enrollment:** 31 (ACTUAL)
- **Why stopped:** Futility analysis determined closure
- **Last updated:** 2025-07-04


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT03333486

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT03333486, "Fludarabine Phosphate, Cyclophosphamide, Total Body Irradiation, and Donor Stem Cell Transplant in Treating Patients With Blood Cancer". Retrieved via AI Analytics 2026-06-03 from https://api.ai-analytics.org/clinical/NCT03333486. Licensed CC0.

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*[Clinical trials dataset](/datasets/clinical-trials) · CC0 1.0*