# Inter- and Intra-individual Variations in Metformin Pharmacokinetics - The Importance of Genes and Drug Interactions

> **NCT03335423** · PHASE1 · COMPLETED · sponsor: **University of Southern Denmark** · enrollment: 228 (actual)

## Conditions studied

- Metformin
- Organic Cation Transporter 1
- Codeine

## Interventions

- **DRUG:** Oral metformin
- **DRUG:** Intravenous metformin
- **DRUG:** Oral codeine and oral metformin
- **DRUG:** Oral codeine and intravenous metformin

## Key facts

- **NCT ID:** NCT03335423
- **Lead sponsor:** University of Southern Denmark
- **Sponsor class:** OTHER
- **Phase:** PHASE1
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2018-03-01
- **Primary completion:** 2020-06-13
- **Final completion:** 2020-06-13
- **Target enrollment:** 228 (ACTUAL)
- **Last updated:** 2020-06-25


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT03335423

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT03335423, "Inter- and Intra-individual Variations in Metformin Pharmacokinetics - The Importance of Genes and Drug Interactions". Retrieved via AI Analytics 2026-06-25 from https://api.ai-analytics.org/clinical/NCT03335423. Licensed CC0.

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