# CORT125281 Single Ascending Dose (SAD) and Multiple Ascending Dose (MAD)

> **NCT03335956** · PHASE1 · COMPLETED · sponsor: **Corcept Therapeutics** · enrollment: 48 (actual)

## Conditions studied

- Healthy

## Interventions

- **DRUG:** CORT125281, 40mg, fasted
- **DRUG:** Prednisone 25mg, fasted
- **DRUG:** Placebo oral capsule, fasted
- **DRUG:** Pioglitazone 15mg Tablet
- **DRUG:** Placebo oral capsule, fed
- **DRUG:** Prednisone 25mg, fed
- **DRUG:** CORT125281, 120mg, fasted
- **DRUG:** CORT125281, 360mg, fasted
- **DRUG:** CORT125281, 720mg, fasted
- **DRUG:** CORT125281, 360mg, fed
- **DRUG:** CORT125281, 360mg
- **DRUG:** CORT125281, 120mg
- **DRUG:** CORT125281, 180mg
- **DRUG:** CORT125281, 240mg
- **DRUG:** CORT125281, 360mg
- **DRUG:** Placebo oral capsule
- **DRUG:** Placebo oral capsule
- **DRUG:** Placebo oral capsule

## Key facts

- **NCT ID:** NCT03335956
- **Lead sponsor:** Corcept Therapeutics
- **Sponsor class:** INDUSTRY
- **Phase:** PHASE1
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2017-09-21
- **Primary completion:** 2018-05-31
- **Final completion:** 2018-06-25
- **Target enrollment:** 48 (ACTUAL)
- **Last updated:** 2018-07-26


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT03335956

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT03335956, "CORT125281 Single Ascending Dose (SAD) and Multiple Ascending Dose (MAD)". Retrieved via AI Analytics 2026-05-31 from https://api.ai-analytics.org/clinical/NCT03335956. Licensed CC0.

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