# Lithium Effects on the Brain's Functional and Structural Connectome in the Treatment of Bipolar Disorder

> **NCT03336918** · — · ACTIVE_NOT_RECRUITING · sponsor: **Brigham and Women's Hospital** · enrollment: 120 (estimated)

## Conditions studied

- Bipolar Disorder
- Bipolar I Depression
- Bipolar II Depression
- Bipolar Depression
- Depression
- Major Depressive Episode

## Interventions

- **DRUG:** Lithium

## Key facts

- **NCT ID:** NCT03336918
- **Lead sponsor:** Brigham and Women's Hospital
- **Sponsor class:** OTHER
- **Phase:** —
- **Study type:** OBSERVATIONAL
- **Status:** ACTIVE_NOT_RECRUITING
- **Start date:** 2017-12-07
- **Primary completion:** 2025-06-30
- **Final completion:** 2026-06-01
- **Target enrollment:** 120 (ESTIMATED)
- **Last updated:** 2026-02-25


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT03336918

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT03336918, "Lithium Effects on the Brain's Functional and Structural Connectome in the Treatment of Bipolar Disorder". Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/clinical/NCT03336918. Licensed CC0.

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