# Testing AZD1775 inC Combination With Radiotherapy and Chemotherapy in Cervical, Upper Vaginal and Uterine Cancers

> **NCT03345784** · PHASE1 · TERMINATED · sponsor: **National Cancer Institute (NCI)** · enrollment: 10 (actual)

## Conditions studied

- Cervical Carcinoma
- Endometrioid Adenocarcinoma
- Malignant Female Reproductive System Neoplasm
- Recurrent Cervical Carcinoma
- Stage I Uterine Corpus Cancer AJCC v7
- Stage I Vaginal Cancer AJCC v6 and v7
- Stage IA Uterine Corpus Cancer AJCC v7
- Stage IB Cervical Cancer AJCC v6 and v7
- Stage IB Uterine Corpus Cancer AJCC v7
- Stage IB2 Cervical Cancer AJCC v6 and v7
- Stage II Cervical Cancer AJCC v7
- Stage II Uterine Corpus Cancer AJCC v7
- Stage II Vaginal Cancer AJCC v6 and v7
- Stage IIA Cervical Cancer AJCC v7
- Stage IIB Cervical Cancer AJCC v6 and v7
- Stage III Cervical Cancer AJCC v6 and v7
- Stage III Uterine Corpus Cancer AJCC v7
- Stage III Vaginal Cancer AJCC v6 and v7
- Stage IIIA Cervical Cancer AJCC v6 and v7
- Stage IIIA Uterine Corpus Cancer AJCC v7
- Stage IIIB Cervical Cancer AJCC v6 and v7
- Stage IIIB Uterine Corpus Cancer AJCC v7
- Stage IIIC Uterine Corpus Cancer AJCC v7
- Vaginal Carcinoma

## Interventions

- **DRUG:** Adavosertib
- **DRUG:** Cisplatin
- **RADIATION:** External Beam Radiation Therapy

## Key facts

- **NCT ID:** NCT03345784
- **Lead sponsor:** National Cancer Institute (NCI)
- **Sponsor class:** NIH
- **Phase:** PHASE1
- **Study type:** INTERVENTIONAL
- **Status:** TERMINATED
- **Start date:** 2018-05-29
- **Primary completion:** 2022-05-10
- **Final completion:** 2022-05-10
- **Target enrollment:** 10 (ACTUAL)
- **Why stopped:** Inadequate accrual rate
- **Last updated:** 2024-02-20


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT03345784

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT03345784, "Testing AZD1775 inC Combination With Radiotherapy and Chemotherapy in Cervical, Upper Vaginal and Uterine Cancers". Retrieved via AI Analytics 2026-05-28 from https://api.ai-analytics.org/clinical/NCT03345784. Licensed CC0.

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